This research project focused on developing enzyme-based strategies for sustainable chemical transformations, addressing challenges in oxidation chemistry, lignin valorization, and imine reduction. The aim is to expand the biocatalytic toolbox for the synthesis of N-heterocyclic pharmaceuticals by enhancing regio-, chemo-, and enantioselectivity. In parallel, enzymatic approaches for lignin valorization have been developed to convert plant-derived aromatic compounds into valuable chemical building blocks.
Lim G, Calabrese D, Wolder A, et al. H2-driven biocatalysis for flavin-dependent ene-reduction in a continuous closed-loop flow system utilizing H2 from water electrolysis. Commun Chem. 2024;7(1). doi:10.1038/s42004-024-01288-y
Link to publication:10.1038/s42004-024-01288-y
Borlinghaus N, Calabrese D, Lauterbach L, Nestl BM. Synthesis of Substituted Acyclic and Cyclic N-Alkylhydrazines by Enzymatic Reductive Hydrazinations. ChemBioChem. 2025;26(4). doi:10.1002/cbic.202400700
Link to publication: 10.1002/cbic.202400700
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