Results from Federico Di Bisceglie (ESR 09)

Federico Di Bisceglie succeeded in designing a membrane contactor, which was subsequently implemented into the gas bioreactor allowing to reach biomass of up to 10 g/L under autotrophy conditions in a reduced hydrogen atmosphere. Then isopropanol production was demonstrated in this membrane contactor bioreactor, allowing to produce up to 1.4 g/L isopropanol from CO2 under low H2 atmosphere. This study provides a proof of concept that molecules production from CO2/H2/O2 is possible in C. necator under low H2 atmosphere which rends the process much safer. He also worked on small scale  design for aerobic autotrophic cultivation.

Di Bisceglie, F. et al. Conceptual Approach for Aerobic Autotrophic Gas Cultivation in Shake Flasks: Overcoming the Inhibitory Effects of Oxygen in Cupriavidus necator. Biotechnol. J. 20, (2025). doi: 10.1002/biot.202400641

Link to publication:10.1002/biot.202400641

Please fiind all ConCO2rde publications and data (coming soon) at our ConCO2rde community at Zenodo:

Zenodo ConCO2rde community

Cookie Consent mit Real Cookie Banner